[Considerations in the transgender population regarding HIV infection, antiretroviral therapy, pre-exposure prophylaxis (PreP) and interaction with gender reaffirmation treatment]. / Consideraciones en población transgénero respecto a la infección por VIH, terapia antiretroviral, profilaxis preexposición (PreP) e interacción con tratamiento de reafirmación de género.

HIV infection is a global epidemic, with a prevalence of 0.8%. In Latin America, Chile, Brazil and Uruguay are the countries with the highest rates. The transgender population is the most affected (OR of 48.8 compared to the general population). Multiple bio-psycho-social factors explain these issues. The low use of condoms for pressure from the partner, the idea of reaffirmation of gender, the fear to be replaced by a cisgender person, the presence of commercial sex, among others, influence the highest rates of infection. HIV prevention measures have been implemented, but few specifically targeted at transgender people. Pre-exposure prophylaxis (PreP) seems to be a new prevention alternative in this group, and the integration of support units in gender reaffirmation with units that deliver PreP could increase their adherence and coverage. In HIV (+) transgender people there is low adherence to antiretroviral therapy (ART), in part due to the prioritization of hormonal treatment and the fear that ART will alter their hormonalization process. The few data that exist show that hormonalization is not affected by ART, but that some hormonal treatments could lower the levels of certain antiretrovirals. More studies must be done to evaluate the interaction between antiretrovirals and gender affirming hormone therapy.

Consideraciones en población transgénero respecto a la infección por VIH, terapia antiretroviral, profilaxis preexposición (PreP) e interacción con tratamiento de reafirmación de género / Considerations in the transgender population regarding HIV infection, antiretroviral therapy, pre-exposure prophylaxis (PreP) and interaction with gender reaffirmation treatment

Resumen La infección por VIH es una epidemia global (prevalencia de 0,8%). En Latinoamérica, Chile, Brasil y Uruguay son los países con mayores índices. Entre las más afectadas están la población transgénero (OR 48,8 respecto a la población general). Múltiples factores bio-psico-sociales explican estas cifras. Bajo uso del preservativo, la idea de reafirmación de género, el temor a ser reemplazadas(os) por personas cisgéneros, presencia de comercio sexual, entre otros, influyen en las mayores tasas de infección. Se han implementado medidas de prevención del VIH, pero pocas dirigidas en específico a personas transgénero. La profilaxis preexposición (PreP) parece ser una nueva alternativa de prevención en este grupo, y la integración de las unidades de apoyo en la reafirmación de género con las unidades que entregan PreP, podrían aumentar su adherencia y cobertura. En las personas transgénero con infección por VIH existe baja adherencia a terapia antirretroviral (TARV), en parte por priorización del tratamiento hormonal y miedo a que la TARV altere su proceso de hormonización. Los pocos datos existentes muestran que la hormonización no se afecta con la mayoría de la TARV, pero algunos tratamientos hormonales podrían disminuir las concentraciones plasmáticas y tisulares de ciertos antirretrovirales. Faltan estudios que evalúen la interacción entre antirretrovirales y tratamiento hormonal de reafirmación de género.

Abstract HIV infection is a global epidemic, with a prevalence of 0.8%. In Latin America, Chile, Brazil and Uruguay are the countries with the highest rates. The transgender population is the most affected (OR of 48.8 compared to the general population). Multiple bio-psycho-social factors explain these issues. The low use of condoms for pressure from the partner, the idea of reaffirmation of gender, the fear to be replaced by a cisgender person, the presence of commercial sex, among others, influence the highest rates of infection. HIV prevention measures have been implemented, but few specifically targeted at transgender people. Pre-exposure prophylaxis (PreP) seems to be a new prevention alternative in this group, and the integration of support units in gender reaffirmation with units that deliver PreP could increase their adherence and coverage. In HIV (+) transgender people there is low adherence to antiretroviral therapy (ART), in part due to the prioritization of hormonal treatment and the fear that ART will alter their hormonalization process. The few data that exist show that hormonalization is not affected by ART, but that some hormonal treatments could lower the levels of certain antiretrovirals. More studies must be done to evaluate the interaction between antiretrovirals and gender affirming hormone therapy.

Percepción de la atención de salud de personas transgénero en profesionales médicos y médicas del norte de Chile / Perception of transgender health care among physicians in northern Chile

RESUMEN La demanda de atención de salud en personas transgénero está creciendo. Existe escasa información del conocimiento de los médicos sobre el trato en la atención sanitaria de estas personas y sus necesidades. Se realizó una encuesta a médicos (as) en Chile sobre su oportunidad de atención a estas personas, su conocimiento sobre las normativas de trato a esta población y percepción sobre acceso a tratamientos de readecuación sexual. De 123 encuestados, edad promedio 41 años, 56% había atendido a alguna persona transgénero, 4,3% manifestó rechazo u odio en esa atención, 84% nunca tuvo alguna formación respecto al tema en su formación universitaria, 96% se mostró interesado en recibir información respecto al tema, 77% desconoce la existencia de normativas de trato a estas personas, 18% rechaza gasto de salud en apoyo a su proceso de readecuación sexual, 14% no usaría el nombre social en el trato con estos pacientes y 10% hospitalizaría a un paciente transgénero según su sexo biológico y no según su sexo sentido. Los médicos en Chile reciben escasa formación respecto al trato y las necesidades de salud de la población transgénero, pero están interesados en que se les entregue información respecto al tema. La mayoría están a favor de que personas transgéneros tengan la oportunidad de recibir apoyo médico en la atención sanitaria pública, en su proceso de reasignación de sexo hormonal y/o quirúrgica.

ABSTRACT The demand for health care in transgender people is growing. There is poor information on physician knowledge about the treatment of these people and their needs. A survey was conducted to physician in Chile about their opportunity to care for these people, their knowledge about the rules of treatment of this population, and their perception of access to sexual rehabilitation treatments. 123 respondents, average age 41 years, 56% had attended some transgender people, 4.3% expressed rejection or hatred in that attention, 84% never had any training on the subject in their university education, 96% were interested in receiving information on the subject, 77% are unaware of the existence of treatment regulations for these people, 18% reject health spending in support of their sexual rehabilitation process, 14% would not use the social name in dealing with these patients and 10% would hospitalize a transgender patient according to their biological sex and not according to their felt sex. Physician in Chile receive poor training regarding the treatment and health needs of the transgender population, but are interested in being given information on the subject. The majority are in favor of transgender people having the opportunity to receive medical support in public health care, in their process of reassignment of hormonal and / or surgical sex.

Síndrome de Cushing provocado por carcinoma suprarrenal gigante. Caso clínico

We report a previously healthy 34-year-old woman, presenting with a seven-month history of arterial hypertension, amenorrhea, weight gain, facial edema, acne, hirsutism and low back pain. A CT scan showed a right adrenal mass of 18 × 13 × 12.5 cm, and multiple vertebral and rib fractures. The hormonal study confirmed Cushing's Syndrome. Ketoconazole, spironolactone, cotrimoxazole, calcium / vitamin D were started. An adrenalectomy with a right nephrectomy were performed. The excised tumor measured 16 cm and weighed 1.55 kg. There was tumor embolism and a 4 mm soft tissue involvement (pT3NxMx). The right kidney was free of tumor. The patient was treated with chemotherapy (etoposide plus cisplatin). Study of vertebral fractures with magnetic resonance (MRI) showed crush fractures, without images of metastatic bone lesions. One year after surgery, a CT scan showed no signs of tumor recurrence. The patient was lost from follow-up thereafter.

Salud mental en trabajadores de la salud durante la pandemia por COVID-19 en Chile

Background: COVID-19 has effects on the mental health of health care workers. Aim: To explore the presence of symptoms associated with mental health problems and associated risk factors in health workers. Material and Methods: The questionnaires PHQ-9 for depression, GAD-7 for anxiety, ISI-7 for insomnia and IES-R-22 for psychological distress were applied to 125 health care workers aged 18 to 67 years (32 physicians, 22 nurses and 71 of other professions) laboring in hospitals and primary care facilities along Chile. Results: Sixty five percent reported depression symptoms, 74% anxiety, 65% insomnia and 57% distress. Physicians had lower median scores in all scales than nurses and other health professionals. Professionals attending patients with respiratory infections or with COVID-19 had higher median scores in the scales that their counterparts. Conclusions: The frequency of mental health problems among these professionals is high and preventive measures should be taken.

[Cushing syndrome caused by a giant adrenal carcinoma. Report of one case]. / Síndrome de Cushing provocado por carcinoma suprarrenal gigante. Caso clínico.

We report a previously healthy 34-year-old woman, presenting with a seven-month history of arterial hypertension, amenorrhea, weight gain, facial edema, acne, hirsutism and low back pain. A CT scan showed a right adrenal mass of 18 × 13 × 12.5 cm, and multiple vertebral and rib fractures. The hormonal study confirmed Cushing's Syndrome. Ketoconazole, spironolactone, cotrimoxazole, calcium / vitamin D were started. An adrenalectomy with a right nephrectomy were performed. The excised tumor measured 16 cm and weighed 1.55 kg. There was tumor embolism and a 4 mm soft tissue involvement (pT3NxMx). The right kidney was free of tumor. The patient was treated with chemotherapy (etoposide plus cisplatin). Study of vertebral fractures with magnetic resonance (MRI) showed crush fractures, without images of metastatic bone lesions. One year after surgery, a CT scan showed no signs of tumor recurrence. The patient was lost from follow-up thereafter.

[Mental health problems among health care workers during the COVID-19 pandemic]. / Salud mental en trabajadores de la salud durante la pandemia por COVID-19 en Chile.

BACKGROUND: COVID-19 has effects on the mental health of health care workers. AIM: To explore the presence of symptoms associated with mental health problems and associated risk factors in health workers. MATERIAL AND METHODS: The questionnaires PHQ-9 for depression, GAD-7 for anxiety, ISI-7 for insomnia and IES-R-22 for psychological distress were applied to 125 health care workers aged 18 to 67 years (32 physicians, 22 nurses and 71 of other professions) laboring in hospitals and primary care facilities along Chile. RESULTS: Sixty five percent reported depression symptoms, 74% anxiety, 65% insomnia and 57% distress. Physicians had lower median scores in all scales than nurses and other health professionals. Professionals attending patients with respiratory infections or with COVID-19 had higher median scores in the scales that their counterparts. CONCLUSIONS: The frequency of mental health problems among these professionals is high and preventive measures should be taken.

Manejo subóptimo de fracturas por fragilidad en el Servicio de Traumatología del Hospital de Antofagasta / Suboptimal management of Frailty fractures in Traumatology Service of the Antofagasta Hospital

Existe escasa información respecto al estudio y manejo de la osteoporosis en los pacientes que han sufrido fractura por fragilidad en Chile. Objetivo: Describir la epidemiologia, aproximación diagnóstica y manejo realizado a pacientes hospitalizados por fractura por fragilidad (muñeca, cadera, columna) que ingresaron al Servicio de Traumatología (ST) del Hospital de Antofagasta (HRA). Método: Estudio retrospectivo, se revisó registros de pacientes hospitalizados en ST y se identificó a pacientes que presentaron fractura por fragilidad. Se revisó sus fichas clínicas (período enero 2015-diciembre 2016). Se analizaron factores de riesgos, exámenes realizados, terapias y controles médicos al alta. Resultados: Fueron 971 ingresos y 100 pacientes con fractura por fragilidad. 88% fueron mujeres cuya edad promedio fue 73,1 años. El factor de riesgo más común fue la postmenopausia y antecedente de fractura previa. Las fracturas se distribuyeron en cadera 64%, muñeca 35% y columna 1%. A solo 3 pacientes se le pidió densitometría ósea. En ninguno fue evaluada vitamina D ni PTH. Al 7% se indicó calcio y vitamina D post fractura, a 4% se indicó antiresortivos. En ningún paciente se promovió el consumo de lácteos. Discusión: Las fracturas osteoporóticas en el HRA son inadecuadamente estudiadas para descarte de factores modificables y son farmacológicamente subtratadas, con el riesgo de nueva aparición de fracturas por fragilidad y morbimortalidad asociada. Es importante reforzar en los servicios de traumatología la importancia del manejo médico postfracturas y eventualmente incorporar la participación de otros especialistas en el manejo de estos pacientes durante la hospitalización y al alta.

We have poor information regarding study and management of osteoporosis in patient who have a fragility fracture in Chile. Objetive: Describe epidemiology, diagnostic approach and management performed on patients hospitalized for fragility fracture in Traumatology Service(ST) of the Antofagasta Hospital(HRA). Method: Retrospective study, we reviewed your clinical record (period January 2015-December 2016). Risk factor, laboratory test performed, therapies and medical controls at discharge were analyzed. Resuls: 971 patient admited to ST, 100 were fragility fracture. 88% were women with average age 73,1 years old. The mosts commons risk factors were chronic kidney failure and anticonvulsants treatment. The fractures were 64% of hip, 35% wrist, and 1% column. Only 3 patients have bone densitometry. None had vitamin D or PTH evaluated. Calcium and vitamin D after fracture were indicated at 7%, antiresorptives were indicated at 4%. In none diary consumption were promoted. Discussion: Osteoporotic fractures in HRA are inadequately studied to rule out modifiable factors and they are pharmacologically subtracted, with risk of new fractures an mobility and mortality. Is important remember in the ST importance of the medical management postfracture and the multidisciplinary work.

[Healthcare of transgenders by non-specialists in Chile]. / Atención de salud de personas transgéneros para médicos no especialistas en Chile.

The health care demand for transgenders has increased in Chile and worldwide. However, in Chile health care professionals are not trained to understand and face this problem. We herein review issues that should be considered in the training of non-specialist physicians to provide health care to transgenders, issues about terminology of body reassignment treatments and gender identity and the way Chilean professionals should deal with transgender persons.

Atención de salud de personas transgéneros para médicos no especialistas en Chile / Healthcare of transgenders by non-specialists in Chile

The health care demand for transgenders has increased in Chile and worldwide. However, in Chile health care professionals are not trained to understand and face this problem. We herein review issues that should be considered in the training of non-specialist physicians to provide health care to transgenders, issues about terminology of body reassignment treatments and gender identity and the way Chilean professionals should deal with transgender persons.